LYRICA is a prescription medicine used in adults, 18 years and older, to treat:
• pain from damaged nerves (neuropathic pain) that happens with diabetes
• pain from damaged nerves (neuropathic pain) that follows healing of
shingles (a painful rash that comes after a herpes zoster infection)
• partial seizures when taken together with other seizure medicines
• fibromyalgia
LYRICA has not been studied in children under 18 years of age.

Pain from Damaged Nerves (neuropathic pain)
Diabetes and shingles can damage your nerves. Pain from damaged nerves may
feel sharp, burning, tingling, shooting, or numb. If you have diabetes, the pain
can be in your arms, hands, fingers, legs, feet, or toes. If you have shingles, the
pain is in the area of your rash. You may experience this kind of pain even with a
very light touch. LYRICA can help relieve the pain. Some people taking LYRICA
had less pain by the end of the first week of LYRICA therapy. LYRICA may not
work for everyone.

Partial Seizures
Partial seizures start in one part of the brain. A seizure can make you fearful,
confused, or just feel "funny". You may smell strange smells. A seizure may
cause your arm or leg to jerk or shake. It can spread to other parts of your
brain, make you pass out, and cause your whole body to start jerking.
LYRICA can lower the number of seizures for people who are already taking
seizure medicine.

Fibromyalgia
Fibromyalgia is a condition which includes widespread muscle pain and difficulty
performing daily activities. LYRICA can help relieve the pain and improve
function. Some people taking LYRICA had less pain by the end of the first week
of LYRICA therapy. LYRICA may not work for everyone.

Who Should Not Take LYRICA?
Do not take LYRICA if you are allergic to any of its ingredients. The
active ingredient is pregabalin. See the end of this leaflet for a complete list of
ingredients in LYRICA.

What should I tell my doctor before taking LYRICA?
Tell your doctor about all your medical conditions, including if you:
• have any kidney problems or get kidney dialysis
• have heart problems including heart failure
• have a bleeding problem or a low blood platelet count
• are pregnant or plan to become pregnant. It is not known if LYRICA
may harm your unborn baby. You and your doctor will have to decide if
LYRICA is right for you while you are pregnant.
• are breastfeeding. It is not known if LYRICA passes into breast milk and
if it can harm your baby. You and your doctor should decide whether you
should take LYRICA or breastfeed, but not both.
Tell your doctor about all the medicines you take including prescription
or non- prescription medicines, vitamins or herbal supplements. LYRICA
and other medicines may affect each other. Especially tell your doctor if you
take:
• angiotensin converting enzyme (ACE) inhibitors. You may have a higher
chance for swelling and hives if these medicines are taken with LYRICA.
See "What is the most important information I should know about
LYRICA?"
• Avandia®(rosiglitazone) or Actos®(pioglitazone) for diabetes. You may
have a higher chance of weight gain or swelling if these medicines are
taken with LYRICA. See "What are the possible side effects of LYRICA."
• any narcotic pain medicine (such as oxycodone), tranquilizers or
medicines for anxiety (such as lorazepam). You may have a higher chance
for dizziness and sleepiness if these medicines are taken with LYRICA. See
"What is the most important information I should know about LYRICA?"
• any medicines that make you sleepy
Know all the medicines you take. Keep a list of them with you to show your
doctor and pharmacist each time you get a new medicine.
Tell your doctor if you plan to father a child. Animal studies showed that
pregabalin, the active ingredient in LYRICA, made male animals less fertile and
caused sperm abnormalities. Also, in animal studies, birth defects occurred in the
offspring of male animals who were treated with pregabalin. It is not known if
these effects would happen in people.

How should I take LYRICA?
• Take LYRICA exactly as prescribed. Your doctor may adjust your dose
during treatment. Do not change your dose without talking to your doctor.
• Do not stop taking LYRICA suddenly without talking to your doctor. If you
stop taking LYRICA suddenly, you may have headaches, nausea, diarrhea
or trouble sleeping. Talk with your doctor about how to slowly stop
LYRICA.
• LYRICA is usually taken 2 or 3 times a day, depending on your medical
condition. Your doctor will tell you how much LYRICA to take and when to
take it. Take LYRICA at the same times each day.
• LYRICA may be taken with or without food.
• If you miss a dose by a few hours, take it as soon as you remember. If it
is close to your next dose, just take LYRICA at your next regular time. Do
not take two doses at the same time.
• If you take too much LYRICA, call your doctor or poison control center or
go to the nearest emergency room right away.

What Should I Avoid While Taking LYRICA?
• Do not drive a car, work with machines, or do other dangerous
activities until you know how LYRICA affects how alert you are.
See "What is the most important information I should know about
LYRICA?"
• Do not drink alcohol while taking LYRICA. LYRICA and alcohol can
affect each other and increase side effects such as sleepiness and
dizziness. This can be dangerous.
Do not take other medicines without talking to your doctor. Other
medicines include prescription and non-prescription medicines, vitamins, and
herbal supplements. LYRICA and other medicines may affect each other and
increase the side effects of swelling, sleepiness and dizziness. Be especially
careful about medicines that make you sleepy (such as sleeping pills, anxiety
medicines, tranquilizers and some antihistamines, pain relievers and seizure
medicines).

What are the possible side effects of LYRICA?
LYRICA may cause side effects including:
• allergic reactions. See "What is the most important information I should
know about LYRICA?"
• weight gain and swelling of the hands and feet (edema). Weight
gain may affect the management of diabetes. Weight gain and swelling
can also be a serious problem for people with heart problems.
• dizziness and sleepiness. See "What is the most important information
I should know about LYRICA?"
• eyesight problems. See "What is the most important information I
should know about LYRICA?"
• unexplained muscle problems, such as muscle pain, soreness, or
weakness. If you develop these symptoms, especially if you also feel sick
and have a fever, tell your doctor right away.

The most common side effects of LYRICA are:
• dizziness
• blurry vision
• weight gain
• sleepiness
• trouble concentrating
• swelling of hands and feet
• dry mouth
LYRICA caused skin sores in animals. Although skin sores were not seen in
studies in people, if you have diabetes, you should pay extra attention to your
skin while taking LYRICA and tell your doctor of any sores or skin problems.
LYRICA may cause some people to feel "high." Tell your doctor, if you have
abused prescription medicines, street drugs, or alcohol in the past.
Tell your doctor about any side effect that bothers you or that does not go away.
These are not all the side effects of LYRICA. For more information, ask your
doctor or pharmacist.

How should I store LYRICA?
• Store LYRICA at room temperature, 59 to 86° F (15 to 30° C) in its original
package.
• Safely throw away LYRICA that is out of date or no longer needed.
• Keep LYRICA and all medicines out of the reach of children.